Jolted by the Great Depression of the 1930s, Thurman Arnold devised an anti-monopoly industrial policy for the United States Justice Department that breathed fresh life into a then-moribund Sherman Anti-Trust Act. Arnold’s jurisprudence built on Adam Smith’s discovery that market-making could promote national security and forestall civil unrest. Smith’s insights had informed the industrial policy of Alexander Hamilton, who laid the groundwork in the 1790s for the country’s economic development. Edward H. Levi brought Arnold’s pragmatic anti-monopolism to the University of Chicago. Here, ironically, Arnoldian jurisprudence would be transmogrified into the doctrinaire company-over-country market fundamentalism of the Chicago School of Economics. Today, writes Richard R. John, as we envision for the 21st century a new pro-market, pro-freedom, pro-national security industrial policy, it is worth recalling how U. S. economic development took the form that it did, why the Chicago School repudiated the enduring wisdom of Adam Smith, and what this portends for the world of today.